› 5lfy

Solution NMR

Zinc bound dimer of the fragment of human amyloid-beta peptide with Alzheimer's disease pathogenic Taiwanese mutation D7H

Released:
DOI: 10.2210/pdb5lfy/pdb
PDB entry 5lfy coloured by chain, ensemble of 20 models, front view.
PDB entry 5lfy coloured by chain, ensemble of 20 models, side view.
PDB entry 5lfy coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
A Binuclear Zinc Interaction Fold Discovered in the Homodimer of Alzheimer's Amyloid-β Fragment with Taiwanese Mutation D7H.
Polshakov VI, Mantsyzov AB, Kozin SA, Adzhubei AA, Zhokhov SS, van Beek W, Kulikova AA, Indeykina MI, Mitkevich VA, Makarov AA
Angew Chem Int Ed Engl 56 11734-11739 (2017)
PMID: 28570778

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138395 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Amyloid-beta protein 40 Chains: A, B
Molecule details ›
Chains: A, B
Length: 11 amino acids
Theoretical weight: 1.22 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P05067 (Residues: 672-681; Coverage: 1%)
Gene names: A4, AD1, APP

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 38%
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

6 review citations

Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer's Disease, Parkinson's Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis.
Nguyen et al. (2021)
5 more