› 5l8n

X-ray diffraction
2.12Å resolution

crystal structure of human FABP6 protein with fragment 1

Released:
DOI: 10.2210/pdb5l8n/pdb
PDB entry 5l8n coloured by chain, front view.
PDB entry 5l8n coloured by chain, side view.
PDB entry 5l8n coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Identification and Investigation of Novel Binding Fragments in the Fatty Acid Binding Protein 6 (FABP6).
Hendrick AG, Müller I, Willems H, Leonard PM, Irving S, Davenport R, Ito T, Reeves J, Wright S, Allen V, Wilkinson S, Heffron H, Bazin R, Turney J, Mitchell PJ
J Med Chem 59 8094-102 (2016)
PMID: 27500412

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156316 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Gastrotropin Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 128 amino acids
Theoretical weight: 14.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P51161 (Residues: 1-128; Coverage: 100%)
Gene names: FABP6, ILBP, ILLBP
Sequence domains: Lipocalin / cytosolic fatty-acid binding protein family
Structure domains: Lipocalin

Ligands and Environments

3 bound ligands:
Ligand 6RQ 2 x 6RQ
Ligand PEG 4 x PEG
Ligand P33 1 x P33
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P21
Unit cell:
a: 47.25Å b: 64.43Å c: 59.02Å
α: 90° β: 94.27° γ: 90°
R-values:
R R work R free
0.249 0.247 0.305
Expression system: Escherichia coli

Quick links

Citations

2 review citations

FABP4 in obesity-associated carcinogenesis: Novel insights into mechanisms and therapeutic implications.
Liu et al. (2022)
1 more

1 mention without citation

Molecular docking and machine learning analysis of Abemaciclib in colon cancer.
Liñares-Blanco et al. (2020)