› 5l4r

X-ray diffraction
1.45Å resolution

X-ray structure of the adduct between thaumatin and cisplatin

Released:
DOI: 10.2210/pdb5l4r/pdb
PDB entry 5l4r coloured by chain, front view.
PDB entry 5l4r coloured by chain, side view.
PDB entry 5l4r coloured by chain, top view.
Source organism: Thaumatococcus daniellii
Primary publication:
Cisplatin-Protein Interactions: Unexpected Drug Binding to N-Terminal Amine and Lysine Side Chains.
Russo Krauss I, Ferraro G, Merlino A
Inorg Chem 55 7814-6 (2016)
PMID: 27482735

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136331 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thaumatin I Chain: A
Molecule details ›
Chain: A
Length: 207 amino acids
Theoretical weight: 22.23 KDa
Source organism: Thaumatococcus daniellii
Expression system: Escherichia coli
UniProt:
  • Canonical: P02883 (Residues: 23-229; Coverage: 97%)
Sequence domains: Thaumatin family
Structure domains: Thaumatin

Ligands and Environments

4 bound ligands:
Ligand TLA 2 x TLA
Ligand 73M 3 x 73M
Ligand CPT 8 x CPT
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P41212
Unit cell:
a: 57.837Å b: 57.837Å c: 150.159Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.114 0.112 0.154
Expression system: Escherichia coli

Quick links

Citations

4 review citations

The rediscovery of platinum-based cancer therapy.
Rottenberg et al. (2021)
3 more