› 5k6x

X-ray diffraction
2.7Å resolution

Sidekick-2 immunoglobulin domains 1-4, crystal form 1

Released:
DOI: 10.2210/pdb5k6x/pdb
PDB entry 5k6x coloured by chain, front view.
PDB entry 5k6x coloured by chain, side view.
PDB entry 5k6x coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Molecular basis of sidekick-mediated cell-cell adhesion and specificity.
Goodman KM, Yamagata M, Jin X, Mannepalli S, Katsamba PS, Ahlsén G, Sergeeva AP, Honig B, Sanes JR, Shapiro L
Elife 5 (2016)
PMID: 27644106

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180445 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Protein sidekick-2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 384 amino acids
Theoretical weight: 42.39 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6V4S5 (Residues: 22-403; Coverage: 18%)
Gene names: Kiaa1514, Sdk2
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer
3 bound ligands:
Ligand NAG 2 x NAG
Ligand SO4 12 x SO4
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4C
Spacegroup: P21
Unit cell:
a: 55.11Å b: 130.01Å c: 78.39Å
α: 90° β: 100.67° γ: 90°
R-values:
R R work R free
0.195 0.193 0.23
Expression system: Homo sapiens

Quick links

Citations

5 review citations

Adhesion Protein Structure, Molecular Affinities, and Principles of Cell-Cell Recognition.
Honig et al. (2020)
4 more

1 mention without citation

Molecular basis of sidekick-mediated cell-cell adhesion and specificity.
Goodman et al. (2016)