› 5jxx

X-ray diffraction
3Å resolution

Crystal structure of UDP-N-acetylglucosamine O-acyltransferase (LpxA) from Moraxella catarrhalis RH4.

Released:
DOI: 10.2210/pdb5jxx/pdb
PDB entry 5jxx coloured by chain, front view.
PDB entry 5jxx coloured by chain, side view.
PDB entry 5jxx coloured by chain, top view.
Source organism: Moraxella catarrhalis BBH18
Primary publication:
Acyl chain preference and inhibitor identification of Moraxella catarrhalis LpxA: Insight through crystal structure and computational studies.
Pratap S, Kesari P, Yadav R, Dev A, Narwal M, Kumar P
Int J Biol Macromol 96 759-765 (2017)
PMID: 28057571

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-237268 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 257 amino acids
Theoretical weight: 28.04 KDa
Source organism: Moraxella catarrhalis BBH18
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand GOL 11 x GOL
Ligand FLC 2 x FLC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BRUKER AXS MICROSTAR-H
Spacegroup: P21
Unit cell:
a: 79.611Å b: 136.897Å c: 90.585Å
α: 90° β: 91.64° γ: 90°
R-values:
R R work R free
0.238 0.235 0.293
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'

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Citations

2 review citations

Pushing the envelope: LPS modifications and their consequences.
Simpson et al. (2019)
1 more