› 5j81

X-ray diffraction
1.8Å resolution

Crystal structure of Glycoprotein C from Puumala virus in the post-fusion conformation (pH 6.0)

Released:
DOI: 10.2210/pdb5j81/pdb
PDB entry 5j81 coloured by chain, front view.
PDB entry 5j81 coloured by chain, side view.
PDB entry 5j81 coloured by chain, top view.
Source organism: Puumala virus p360
Primary publication:
Crystal Structure of Glycoprotein C from a Hantavirus in the Post-fusion Conformation.
Willensky S, Bar-Rogovsky H, Bignon EA, Tischler ND, Modis Y, Dessau M
PLoS Pathog 12 e1005948 (2016)
PMID: 27783673

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154366 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Glycoprotein C Chain: A
Molecule details ›
Chain: A
Length: 448 amino acids
Theoretical weight: 48.99 KDa
Source organism: Puumala virus p360
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P41266 (Residues: 659-1106; Coverage: 40%)
Gene name: GP
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
3 bound ligands:
Ligand P33 1 x P33
Ligand SO4 1 x SO4
Ligand ACT 1 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: R32
Unit cell:
a: 96.43Å b: 96.43Å c: 247.11Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.184 0.183 0.209
Expression system: Trichoplusia ni

Quick links

Citations

9 review citations

Common Features of Enveloped Viruses and Implications for Immunogen Design for Next-Generation Vaccines.
Rey et al. (2018)
8 more

5 mentions without citation

Application of viromics: a new approach to the understanding of viral infections in humans.
Ramamurthy et al. (2017)
4 more