› 5iix

X-ray diffraction
2.2Å resolution

Crystal structure of Equine Serum Albumin in the presence of 15 mM zinc at pH 6.5

Released:
DOI: 10.2210/pdb5iix/pdb
PDB entry 5iix coloured by chain, front view.
PDB entry 5iix coloured by chain, side view.
PDB entry 5iix coloured by chain, top view.
Source organism: Equus caballus
Primary publication:
Circulatory zinc transport is controlled by distinct interdomain sites on mammalian albumins.
Handing KB, Shabalin IG, Kassaar O, Khazaipoul S, Blindauer CA, Stewart AJ, Chruszcz M, Minor W
Chem Sci 7 6635-6648 (2016)
PMID: 28567254

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153012 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Albumin Chain: A
Molecule details ›
Chain: A
Length: 583 amino acids
Theoretical weight: 65.77 KDa
Source organism: Equus caballus
UniProt:
  • Canonical: P35747 (Residues: 25-607; Coverage: 99%)
Gene name: ALB
Sequence domains: Serum albumin family
Structure domains: Serum Albumin; Chain A, Domain 1

Ligands and Environments

3 bound ligands:
Ligand ZN 11 x ZN
Ligand UNL 2 x UNL
Ligand SO4 6 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-G
Spacegroup: P61
Unit cell:
a: 94.313Å b: 94.313Å c: 141.485Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.181 0.178 0.228

Quick links

Citations

13 review citations

Cisplatin and beyond: molecular mechanisms of action and drug resistance development in cancer chemotherapy.
Makovec T. (2019)
12 more

2 mentions without citation

Characterizing metal-binding sites in proteins with X-ray crystallography.
Handing et al. (2018)
1 more