Function and Biology Details
Reaction catalysed:
Thioredoxin + ROOH = thioredoxin disulfide + H(2)O + ROH
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171579 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Peroxiredoxin-4
Molecule details ›
Chains: A, B
Length: 246 amino acids
Theoretical weight: 28.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains:
Structure domains: Glutaredoxin
Length: 246 amino acids
Theoretical weight: 28.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
Q13162 (Residues: 38-271; Coverage: 100%)
Sequence domains:
Structure domains: Glutaredoxin
Endoplasmic reticulum resident protein 44
Molecule details ›
Chains: C, D
Length: 382 amino acids
Theoretical weight: 44.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains:
Structure domains: Glutaredoxin
Length: 382 amino acids
Theoretical weight: 44.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical: Q9BS26 (Residues: 30-406; Coverage: 100%)
Sequence domains:
Structure domains: Glutaredoxin
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
SSRF BEAMLINE BL19U1
Spacegroup:
C2221
Expression system: Escherichia coli BL21(DE3)
