› 5gt8

X-ray diffraction
2.8Å resolution

Crystal Structure of apo-CASTOR1

Released:
DOI: 10.2210/pdb5gt8/pdb
PDB entry 5gt8 coloured by chain, front view.
PDB entry 5gt8 coloured by chain, side view.
PDB entry 5gt8 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of arginine sensor CASTOR1 in arginine-bound and ligand free states.
Zhou Y, Wang C, Xiao Q, Guo L
Biochem Biophys Res Commun 508 387-391 (2019)
PMID: 30503338

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186705 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Cytosolic arginine sensor for mTORC1 subunit 1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 335 amino acids
Theoretical weight: 36.85 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q8WTX7 (Residues: 1-329; Coverage: 100%)
Gene names: CASTOR1, GATSL3
Sequence domains:
Cytosolic arginine sensor for mTORC1 subunit 1 Chain: D
Molecule details ›
Chain: D
Length: 335 amino acids
Theoretical weight: 36.89 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q8WTX7 (Residues: 1-329; Coverage: 100%)
Gene names: CASTOR1, GATSL3
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P21
Unit cell:
a: 47.41Å b: 142.6Å c: 95.4Å
α: 90° β: 90.26° γ: 90°
R-values:
R R work R free
0.244 0.243 0.265
Expression system: Spodoptera frugiperda

Quick links

Citations

1 review citation

Amino acid-dependent control of mTORC1 signaling: a variety of regulatory modes.
Takahara et al. (2020)

3 mentions without citation

Structural Insights into TOR Signaling.
Tafur et al. (2020)
2 more