5ggv

X-ray diffraction
2Å resolution

CTLA-4 in complex with tremelimumab Fab

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-210683 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
light chain Chain: L
Molecule details ›
Chain: L
Length: 214 amino acids
Theoretical weight: 23.41 KDa
Source organism: Homo sapiens
Expression system: Not provided
Structure domains: Immunoglobulins
heavy chain Chain: H
Molecule details ›
Chain: H
Length: 239 amino acids
Theoretical weight: 25.95 KDa
Source organism: Homo sapiens
Expression system: Not provided
Structure domains: Immunoglobulins
Cytotoxic T-lymphocyte protein 4 Chain: Y
Molecule details ›
Chain: Y
Length: 126 amino acids
Theoretical weight: 13.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli-Pichia pastoris shuttle vector pPpARG4
UniProt:
  • Canonical: P16410 (Residues: 36-161; Coverage: 67%)
Gene names: CD152, CTLA4
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 5C (4A)
Spacegroup: P21212
Unit cell:
a: 131.559Å b: 48.207Å c: 118.714Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.183 0.181 0.214
Expression systems:
  • Not provided
  • Escherichia coli-Pichia pastoris shuttle vector pPpARG4