› 5fxh

Electron Microscopy
6.1Å resolution

GluN1b-GluN2B NMDA receptor in non-active-1 conformation

Released:
DOI: 10.2210/pdb5fxh/pdb
PDB entry 5fxh coloured by chain, front view.
PDB entry 5fxh coloured by chain, side view.
PDB entry 5fxh coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Activation of NMDA receptors and the mechanism of inhibition by ifenprodil.
Tajima N, Karakas E, Grant T, Simorowski N, Diaz-Avalos R, Grigorieff N, Furukawa H
Nature 534 63-8 (2016)
PMID: 27135925
Related structures: EMD-3353

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152911 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Glutamate receptor ionotropic, NMDA 1 Chains: A, C
Molecule details ›
Chains: A, C
Length: 846 amino acids
Theoretical weight: 95.22 KDa
Source organism: Rattus norvegicus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P35439 (Residues: 23-190, 191-847; Coverage: 90%)
Gene names: Grin1, Nmdar1
Sequence domains:
Glutamate receptor ionotropic, NMDA 2B Chains: B, D
Molecule details ›
Chains: B, D
Length: 827 amino acids
Theoretical weight: 92.93 KDa
Source organism: Rattus norvegicus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q00960 (Residues: 27-852; Coverage: 57%)
Gene name: Grin2b
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 6.1Å
Relevant EMDB volumes: EMD-3353
Expression system: Spodoptera frugiperda

Quick links

Citations

26 review citations

Unravelling biological macromolecules with cryo-electron microscopy.
Fernandez-Leiro et al. (2016)
25 more

13 mentions without citation

Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.
Hansen et al. (2021)
12 more