› 5fma

X-ray diffraction
2.46Å resolution

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155479 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neurogenic locus notch homolog protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 154 amino acids
Theoretical weight: 16.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P46531 (Residues: 142-294; Coverage: 6%)
Gene names: NOTCH1, TAN1
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand CA 5 x CA
Ligand CL 2 x CL
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P21
Unit cell:
a: 40.94Å b: 86.83Å c: 53.45Å
α: 90° β: 107.58° γ: 90°
R-values:
R R work R free
0.259 0.259 0.263
Expression system: Escherichia coli BL21

Quick links

Citations

6 review citations

The Canonical Notch Signaling Pathway: Structural and Biochemical Insights into Shape, Sugar, and Force.
Kovall et al. (2017)
5 more

1 mention without citation

Naturally occurring NOTCH3 exon skipping attenuates NOTCH3 protein aggregation and disease severity in CADASIL patients.
Gravesteijn et al. (2020)