› 5eko

X-ray diffraction
2Å resolution

Crystal structure of MAPK13 complex with inhibitor

Released:
DOI: 10.2210/pdb5eko/pdb
PDB entry 5eko coloured by chain, front view.
PDB entry 5eko coloured by chain, side view.
PDB entry 5eko coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
First comprehensive structural and biophysical analysis of MAPK13 inhibitors targeting DFG-in and DFG-out binding modes.
Yurtsever Z, Patel DA, Kober DL, Su A, Miller CA, Romero AG, Holtzman MJ, Brett TJ
Biochim Biophys Acta 1860 2335-2344 (2016)
PMID: 27369736

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127397 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase 13 Chain: A
Molecule details ›
Chain: A
Length: 371 amino acids
Theoretical weight: 42.63 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O15264 (Residues: 1-352; Coverage: 96%)
Gene names: MAPK13, PRKM13, SAPK4
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand N17 1 x N17
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P212121
Unit cell:
a: 61.263Å b: 69.669Å c: 93.068Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.202 0.2 0.241
Expression system: Escherichia coli

Quick links

Citations

6 review citations

p38γ and p38δ: From Spectators to Key Physiological Players.
Cuenda et al. (2017)
5 more

2 mentions without citation

The complete structure of an activated open sodium channel.
Sula et al. (2017)
1 more