› 5eiv

X-ray diffraction
2.41Å resolution

Crystal structure of complex of osteoclast-associated immunoglobulin-like receptor (OSCAR) and a synthetic collagen consensus peptide

Released:
DOI: 10.2210/pdb5eiv/pdb
PDB entry 5eiv coloured by chain, front view.
PDB entry 5eiv coloured by chain, side view.
PDB entry 5eiv coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for collagen recognition by the immune receptor OSCAR.
Zhou L, Hinerman JM, Blaszczyk M, Miller JL, Conrady DG, Barrow AD, Chirgadze DY, Bihan D, Farndale RW, Herr AB
Blood 127 529-37 (2016)
PMID: 26552697

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
hetero octamer (preferred)
homo trimer
Assembly name:
PDBe Complex ID:
PDB-CPX-165600 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Osteoclast-associated immunoglobulin-like receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 203 amino acids
Theoretical weight: 22.29 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8IYS5 (Residues: 26-215; Coverage: 72%)
Gene name: OSCAR
Sequence domains: Immunoglobulin domain
Structure domains: Immunoglobulins
GLY-PRO-HYP-GLY-PRO-HYP-GLY-PRO-HYP-GLY-PRO-ALA-GLY-PHE-HYP-GLY-PRO-HYP-GLY-PRO-HYP Chains: C, D, E, F, G, H
Molecule details ›
Chains: C, D, E, F, G, H
Length: 21 amino acids
Theoretical weight: 1.9 KDa
Source organism: Homo sapiens
Expression system: Not provided
PRO-GLY-PRO-PRO-GLY-PRO-PRO Chains: I, J, K
Molecule details ›
Chains: I, J, K
Length: 7 amino acids
Theoretical weight: 666 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

5 bound ligands:
Ligand NAG 2 x NAG
Ligand SO4 4 x SO4
Ligand CL 3 x CL
Ligand NA 2 x NA
Ligand ACT 1 x ACT
1 modified residue:
Ligand HYP 45 x HYP

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P21
Unit cell:
a: 38.707Å b: 136.585Å c: 70.584Å
α: 90° β: 90.05° γ: 90°
R-values:
R R work R free
0.176 0.174 0.22
Expression systems:
  • Homo sapiens
  • Not provided

Quick links

Citations

13 review citations

The Natural Cytotoxicity Receptors in Health and Disease.
Barrow et al. (2019)
12 more