› 5eiq

X-ray diffraction
2.01Å resolution

Human OSCAR ligand-binding domain

Released:
DOI: 10.2210/pdb5eiq/pdb
PDB entry 5eiq coloured by chain, front view.
PDB entry 5eiq coloured by chain, side view.
PDB entry 5eiq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for collagen recognition by the immune receptor OSCAR.
Zhou L, Hinerman JM, Blaszczyk M, Miller JL, Conrady DG, Barrow AD, Chirgadze DY, Bihan D, Farndale RW, Herr AB
Blood 127 529-37 (2016)
PMID: 26552697

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184948 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Osteoclast-associated immunoglobulin-like receptor Chain: A
Molecule details ›
Chain: A
Length: 188 amino acids
Theoretical weight: 20.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8IYS5 (Residues: 28-215; Coverage: 71%)
Gene name: OSCAR
Sequence domains: Immunoglobulin domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P21
Unit cell:
a: 26.938Å b: 48.486Å c: 74.945Å
α: 90° β: 91.82° γ: 90°
R-values:
R R work R free
0.181 0.179 0.219
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

12 review citations

The Natural Cytotoxicity Receptors in Health and Disease.
Barrow et al. (2019)
11 more

2 mentions without citation

Role of OSCAR Signaling in Osteoclastogenesis and Bone Disease.
Nedeva et al. (2021)
1 more