› 5dt6

X-ray diffraction
1.6Å resolution

Crystal structure of the Drosophila GluR1A ligand binding domain complex with glutamate

Released:
DOI: 10.2210/pdb5dt6/pdb
PDB entry 5dt6 coloured by chain, front view.
PDB entry 5dt6 coloured by chain, side view.
PDB entry 5dt6 coloured by chain, top view.
Source organism: Drosophila melanogaster
Primary publication:
Novel Functional Properties of Drosophila CNS Glutamate Receptors.
Li Y, Dharkar P, Han TH, Serpe M, Lee CH, Mayer ML
Neuron 92 1036-1048 (2016)
PMID: 27889096

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169892 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor 1 Chain: A
Molecule details ›
Chain: A
Length: 267 amino acids
Theoretical weight: 30.57 KDa
Source organism: Drosophila melanogaster
Expression system: Escherichia coli
UniProt:
  • Canonical: Q03445 (Residues: 474-594, 739-880; Coverage: 27%)
Gene names: CG8442, Glu-RI, GluRIA
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

2 bound ligands:
Ligand GLU 1 x GLU
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P212121
Unit cell:
a: 53.396Å b: 58.351Å c: 100.179Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.155 0.154 0.175
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.
Hansen et al. (2021)
3 more

2 mentions without citation

The structural bases for agonist diversity in an Arabidopsis thaliana glutamate receptor-like channel.
Alfieri et al. (2020)
1 more