› 5dcd

X-ray diffraction
2.31Å resolution

Neisseria meningitidis 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase regulated (Tyrosine)

Released:
DOI: 10.2210/pdb5dcd/pdb
PDB entry 5dcd coloured by chain, front view.
PDB entry 5dcd coloured by chain, side view.
PDB entry 5dcd coloured by chain, top view.
Source organism: Neisseria meningitidis MC58
Entry authors: Heyes LC, Parker E

Function and Biology Details

Reaction catalysed: 
Phosphoenolpyruvate + D-erythrose 4-phosphate + H(2)O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-191737 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phospho-2-dehydro-3-deoxyheptonate aldolase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 351 amino acids
Theoretical weight: 38.71 KDa
Source organism: Neisseria meningitidis MC58
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9K169 (Residues: 1-351; Coverage: 100%)
Gene names: NMB0307, aroG
Sequence domains: DAHP synthetase I family
Structure domains: Aldolase class I

Ligands and Environments

4 bound ligands:
Ligand MN 4 x MN
Ligand SO4 1 x SO4
Ligand TMO 4 x TMO
Ligand TYR 4 x TYR
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX1
Spacegroup: P21
Unit cell:
a: 72.938Å b: 141.292Å c: 74.675Å
α: 90° β: 96.28° γ: 90°
R-values:
R R work R free
0.196 0.194 0.239
Expression system: Escherichia coli

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