› 5cmp

X-ray diffraction
2.6Å resolution

human FLRT3 LRR domain

Released:
DOI: 10.2210/pdb5cmp/pdb
PDB entry 5cmp coloured by chain, front view.
PDB entry 5cmp coloured by chain, side view.
PDB entry 5cmp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural Basis of Latrophilin-FLRT-UNC5 Interaction in Cell Adhesion.
Lu YC, Nazarko OV, Sando R, Salzman GS, Li NS, Südhof TC, Araç D
Structure 23 1678-1691 (2015)
PMID: 26235030

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192788 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Leucine-rich repeat transmembrane protein FLRT3 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 333 amino acids
Theoretical weight: 37.96 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q9NZU0 (Residues: 29-357; Coverage: 53%)
Gene names: FLRT3, KIAA1469, UNQ856/PRO1865
Sequence domains: Leucine rich repeat
Structure domains: Ribonuclease Inhibitor

Ligands and Environments

1 bound ligand:
Ligand NAG 4 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P21
Unit cell:
a: 76.14Å b: 106.581Å c: 84.152Å
α: 90° β: 90.31° γ: 90°
R-values:
R R work R free
0.236 0.232 0.3
Expression system: Trichoplusia ni

Quick links

Citations

22 review citations

Adhesion G protein-coupled receptors in nervous system development and disease.
Langenhan et al. (2016)
21 more

4 mentions without citation

Structural Basis of Latrophilin-FLRT-UNC5 Interaction in Cell Adhesion.
Lu et al. (2015)
3 more