› 5cmk

X-ray diffraction
1.8Å resolution

Crystal structure of the GluK2EM LBD dimer assembly complex with glutamate and LY466195

Released:
DOI: 10.2210/pdb5cmk/pdb
PDB entry 5cmk coloured by chain, front view.
PDB entry 5cmk coloured by chain, side view.
PDB entry 5cmk coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structural basis of kainate subtype glutamate receptor desensitization.
Meyerson JR, Chittori S, Merk A, Rao P, Han TH, Serpe M, Mayer ML, Subramaniam S
Nature 537 567-571 (2016)
PMID: 27580033

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154585 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor ionotropic, kainate 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 259 amino acids
Theoretical weight: 29.36 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P42260 (Residues: 429-544, 667-806; Coverage: 29%)
Gene names: Glur6, Grik2
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

5 bound ligands:
Ligand GLU 1 x GLU
Ligand LI 2 x LI
Ligand CL 2 x CL
Ligand LY5 1 x LY5
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P6122
Unit cell:
a: 102.759Å b: 102.759Å c: 281.992Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.165 0.164 0.187
Expression system: Escherichia coli

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Citations

14 review citations

Glutamatergic Signaling in the Central Nervous System: Ionotropic and Metabotropic Receptors in Concert.
Reiner et al. (2018)
13 more

3 mentions without citation

Structural basis of kainate subtype glutamate receptor desensitization.
Meyerson et al. (2016)
2 more