› 5bzb

X-ray diffraction
2.7Å resolution

NavMs voltage-gated sodium channel pore and C-terminal domain

Released:
DOI: 10.2210/pdb5bzb/pdb
PDB entry 5bzb coloured by chain, front view.
PDB entry 5bzb coloured by chain, side view.
PDB entry 5bzb coloured by chain, top view.
Source organism: Magnetococcus marinus MC-1
Primary publication:
Molecular basis of ion permeability in a voltage-gated sodium channel.
Naylor CE, Bagnéris C, DeCaen PG, Sula A, Scaglione A, Clapham DE, Wallace BA
EMBO J 35 820-30 (2016)
PMID: 26873592

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-106115 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ion transport domain-containing protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 149 amino acids
Theoretical weight: 16.84 KDa
Source organism: Magnetococcus marinus MC-1
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: A0L5S6 (Residues: 130-274; Coverage: 53%)
Gene name: Mmc1_0798
Sequence domains: Ion transport protein
Structure domains: Helix Hairpins

Ligands and Environments

3 bound ligands:
Ligand 12P 3 x 12P
Ligand NA 6 x NA
Ligand 2CV 4 x 2CV
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: C2221
Unit cell:
a: 80.34Å b: 332.763Å c: 80.38Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.18 0.178 0.214
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

15 review citations

The chemical basis for electrical signaling.
Catterall et al. (2017)
14 more

4 mentions without citation

Cryo-electron microscopy structure of the lysosomal calcium-permeable channel TRPML3.
Hirschi et al. (2017)
3 more