› 5ar6

X-ray diffraction
1.25Å resolution

crystal structure of porcine RNase 4

Released:
DOI: 10.2210/pdb5ar6/pdb
PDB entry 5ar6 coloured by chain, front view.
PDB entry 5ar6 coloured by chain, side view.
PDB entry 5ar6 coloured by chain, top view.
Source organism: Sus scrofa
Primary publication:
Structural basis of substrate specificity in porcine RNase 4.
Liang S, Acharya KR
FEBS J 283 912-28 (2016)
PMID: 26748441

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147378 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ribonuclease 4 Chain: A
Molecule details ›
Chain: A
Length: 122 amino acids
Theoretical weight: 14.13 KDa
Source organism: Sus scrofa
Expression system: Escherichia coli
UniProt:
  • Canonical: P15468 (Residues: 29-147; Coverage: 100%)
Gene names: RNASE4, RNS4
Sequence domains: Pancreatic ribonuclease
Structure domains: Ribonuclease A-like domain

Ligands and Environments

1 bound ligand:
Ligand EDO 2 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Unit cell:
a: 36.287Å b: 38.191Å c: 86.92Å
α: 90° β: 97.68° γ: 90°
R-values:
R R work R free
0.126 0.125 0.153
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Immune Modulation by Human Secreted RNases at the Extracellular Space.
Lu et al. (2018)
3 more

2 mentions without citation

Structural basis of substrate specificity in porcine RNase 4.
Liang et al. (2016)
1 more