› 5an8

Electron Microscopy
3.8Å resolution

Cryo-electron microscopy structure of rabbit TRPV2 ion channel

Released:
DOI: 10.2210/pdb5an8/pdb
PDB entry 5an8 coloured by chain, front view.
PDB entry 5an8 coloured by chain, side view.
PDB entry 5an8 coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Primary publication:
Cryo-electron microscopy structure of the TRPV2 ion channel.
Zubcevic L, Herzik MA, Chung BC, Liu Z, Lander GC, Lee SY
Nat Struct Mol Biol 23 180-186 (2016)
PMID: 26779611
Related structures: EMD-6455

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-124210 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ion transport domain-containing protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 613 amino acids
Theoretical weight: 69.91 KDa
Source organism: Oryctolagus cuniculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: G1SNM3 (Residues: 131-763; Coverage: 75%)
Gene name: TRPV2
Sequence domains:
Structure domains: Ankyrin repeat-containing domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.8Å
Relevant EMDB volumes: EMD-6455
Expression system: Spodoptera frugiperda

Quick links

Citations

50 review citations

A structural overview of the ion channels of the TRPM family.
Huang et al. (2020)
49 more

26 mentions without citation

Structural insights into the gating mechanisms of TRPV channels.
Pumroy et al. (2020)
25 more