› 5ajq

X-ray diffraction
2.2Å resolution

Human LOK (STK10) in complex with Bosutinib

Released:
DOI: 10.2210/pdb5ajq/pdb
PDB entry 5ajq coloured by chain, front view.
PDB entry 5ajq coloured by chain, side view.
PDB entry 5ajq coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Elkins JM, Salah E, Pinkas DM, Krojer T, Kopec J, Bountra C, Edwards AM, Knapp S

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131759 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase 10 Chains: A, B
Molecule details ›
Chains: A, B
Length: 295 amino acids
Theoretical weight: 33.44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O94804 (Residues: 21-313; Coverage: 30%)
Gene names: LOK, STK10
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand DB8 2 x DB8
Ligand CL 1 x CL
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Unit cell:
a: 41.19Å b: 108.1Å c: 144.27Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.219 0.217 0.257
Expression system: Escherichia coli BL21(DE3)

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