› 4zkf

X-ray diffraction
1.82Å resolution

Crystal structure of human phosphodiesterase 12

Released:
DOI: 10.2210/pdb4zkf/pdb
PDB entry 4zkf coloured by chain, front view.
PDB entry 4zkf coloured by chain, side view.
PDB entry 4zkf coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Kim SY, Kohno T, Mori T, Kitano K, Hakoshima T

Function and Biology Details

Reaction catalysed: 
Exonucleolytic cleavage of poly(A) to 5'-AMP
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179850 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
2',5'-phosphodiesterase 12 Chain: A
Molecule details ›
Chain: A
Length: 462 amino acids
Theoretical weight: 51.9 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6L8Q7 (Residues: 154-609; Coverage: 75%)
Gene name: PDE12
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand MG 2 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: P212121
Unit cell:
a: 45.817Å b: 99.84Å c: 104.69Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.167 0.166 0.19
Expression system: Escherichia coli

Quick links