› 4zch

X-ray diffraction
2.43Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131157 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tumor necrosis factor ligand superfamily member 13; Tumor necrosis factor ligand superfamily member 13b, soluble form Chains: A, B
Molecule details ›
Chains: A, B
Length: 438 amino acids
Theoretical weight: 48.73 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O75888 (Residues: 115-250; Coverage: 54%)
  • Canonical: Q9Y275 (Residues: 140-285; Coverage: 51%)
Gene names: APRIL, BAFF, BLYS, TALL1, TALL2, TNFSF13, TNFSF13B, TNFSF20, UNQ383/PRO715, UNQ401/PRO738, ZTNF2, ZTNF4
Sequence domains: TNF(Tumour Necrosis Factor) family

Ligands and Environments

1 bound ligand:
Ligand 144 1 x 144
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: C2221
Unit cell:
a: 57.041Å b: 117.865Å c: 295.521Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.179 0.177 0.234
Expression system: Homo sapiens

Quick links

Citations

4 review citations

BAFF and BAFF-Receptor in B Cell Selection and Survival.
Smulski et al. (2018)
3 more

4 mentions without citation

Stoichiometry of Heteromeric BAFF and APRIL Cytokines Dictates Their Receptor Binding and Signaling Properties.
Schuepbach-Mallepell et al. (2015)
3 more