› 4yzn

X-ray diffraction
1.55Å resolution

Humanized Roco4 bound to Compound 19

Released:
DOI: 10.2210/pdb4yzn/pdb
PDB entry 4yzn coloured by chain, front view.
PDB entry 4yzn coloured by chain, side view.
PDB entry 4yzn coloured by chain, top view.
Source organism: Dictyostelium discoideum
Primary publication:
Structural Characterization of LRRK2 Inhibitors.
Gilsbach BK, Messias AC, Ito G, Sattler M, Alessi DR, Wittinghofer A, Kortholt A
J Med Chem 58 3751-6 (2015)
PMID: 25897865

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180528 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Probable serine/threonine-protein kinase roco4 Chain: A
Molecule details ›
Chain: A
Length: 287 amino acids
Theoretical weight: 32.55 KDa
Source organism: Dictyostelium discoideum
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q6XHB2 (Residues: 1019-1292; Coverage: 16%)
Gene names: DDB_G0288251, roco4
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 4K5 1 x 4K5
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P43212
Unit cell:
a: 42.4Å b: 42.4Å c: 326.9Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.189 0.187 0.216
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

The Cell Biology of LRRK2 in Parkinson's Disease.
Usmani et al. (2021)
2 more

2 mentions without citation

Structural binding site comparisons reveal Crizotinib as a novel LRRK2 inhibitor.
Bolz et al. (2021)
1 more