› 4yzf

X-ray diffraction
3.5Å resolution

Crystal structure of the anion exchanger domain of human erythrocyte Band 3

Released:
DOI: 10.2210/pdb4yzf/pdb
PDB entry 4yzf coloured by chain, front view.
PDB entry 4yzf coloured by chain, side view.
PDB entry 4yzf coloured by chain, top view.
Source organisms:
Primary publication:
Crystal structure of the anion exchanger domain of human erythrocyte band 3.
Arakawa T, Kobayashi-Yurugi T, Alguel Y, Iwanari H, Hatae H, Iwata M, Abe Y, Hino T, Ikeda-Suno C, Kuma H, Kang D, Murata T, Hamakubo T, Cameron AD, Kobayashi T, Hamasaki N, Iwata S
Science 350 680-4 (2015)
PMID: 26542571

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-208779 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Band 3 anion transport protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 911 amino acids
Theoretical weight: 101.88 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02730 (Residues: 1-911; Coverage: 100%)
Gene names: AE1, DI, EPB3, SLC4A1
Sequence domains:
FAB fragment of Immunoglobulin (IgG) molecule Chains: E, G, I, K
Molecule details ›
Chains: E, G, I, K
Length: 223 amino acids
Theoretical weight: 23.97 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
FAB fragment of Immunoglobulin (IgG) molecule Chains: F, H, J, L
Molecule details ›
Chains: F, H, J, L
Length: 218 amino acids
Theoretical weight: 24.11 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand 4KU 4 x 4KU
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: C2
Unit cell:
a: 152.825Å b: 171.957Å c: 271.7Å
α: 90° β: 101.16° γ: 90°
R-values:
R R work R free
0.275 0.274 0.29

Quick links

Citations

21 review citations

A guide to plasma membrane solute carrier proteins.
Pizzagalli et al. (2021)
20 more

40 mentions without citation

Carbonic Anhydrases: Role in pH Control and Cancer.
Mboge et al. (2018)
39 more