› 4ywt

X-ray diffraction
2.38Å resolution

Crystal structure of full-length glypican-1 core protein after controlled crystal dehydration to 87% relative humidity

Released:
DOI: 10.2210/pdb4ywt/pdb
PDB entry 4ywt coloured by chain, front view.
PDB entry 4ywt coloured by chain, side view.
PDB entry 4ywt coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural Aspects of N-Glycosylations and the C-terminal Region in Human Glypican-1.
Awad W, Adamczyk B, Örnros J, Karlsson NG, Mani K, Logan DT
J Biol Chem 290 22991-3008 (2015)
PMID: 26203194

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152787 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glypican-1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 526 amino acids
Theoretical weight: 58.51 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P35052 (Residues: 24-527; Coverage: 94%)
Gene name: GPC1
Sequence domains: Glypican

Ligands and Environments

2 bound ligands:
Ligand NAG 4 x NAG
Ligand CA 9 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I911-3
Spacegroup: P21
Unit cell:
a: 46.78Å b: 166.59Å c: 137.7Å
α: 90° β: 90.38° γ: 90°
R-values:
R R work R free
0.24 0.239 0.273
Expression system: Homo sapiens

Quick links

Citations

6 review citations

Generation of extracellular morphogen gradients: the case for diffusion.
Stapornwongkul et al. (2021)
5 more

8 mentions without citation

Multiscale Simulations of Biological Membranes: The Challenge To Understand Biological Phenomena in a Living Substance.
Enkavi et al. (2019)
7 more