› 4yv5

X-ray diffraction
1.9Å resolution

Crystal Structure of Myotoxin II from Bothrops moojeni complexed to Suramin

Released:
DOI: 10.2210/pdb4yv5/pdb
PDB entry 4yv5 coloured by chain, front view.
PDB entry 4yv5 coloured by chain, side view.
PDB entry 4yv5 coloured by chain, top view.
Source organism: Bothrops moojeni
Primary publication:
Structural and functional evidence for membrane docking and disruption sites on phospholipase A2-like proteins revealed by complexation with the inhibitor suramin.
Salvador GH, Dreyer TR, Cavalcante WL, Matioli FF, Dos Santos JI, Velazquez-Campoy A, Gallacci M, Fontes MR
Acta Crystallogr D Biol Crystallogr 71 2066-78 (2015)
PMID: 26457430

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-191508 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Basic phospholipase A2 homolog myotoxin II Chains: A, B
Molecule details ›
Chains: A, B
Length: 122 amino acids
Theoretical weight: 13.91 KDa
Source organism: Bothrops moojeni
UniProt:
  • Canonical: Q9I834 (Residues: 1-122; Coverage: 100%)
Sequence domains: Phospholipase A2
Structure domains: Phospholipase A2 domain

Ligands and Environments

4 bound ligands:
Ligand SO4 7 x SO4
Ligand PE4 1 x PE4
Ligand 1PE 2 x 1PE
Ligand SVR 2 x SVR
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: LNLS BEAMLINE W01B-MX2
Spacegroup: P212121
Unit cell:
a: 50.795Å b: 63.646Å c: 87.721Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.196 0.195 0.227

Quick links

Citations

2 review citations

Exploiting the Achilles' heel of membrane trafficking in trypanosomes.
Zoltner et al. (2016)
1 more

6 mentions without citation

100 Years of Suramin.
Wiedemar et al. (2020)
5 more