› 4yep

X-ray diffraction
1.19Å resolution

L4b Domain of Human Laminin alpha-2

Released:
DOI: 10.2210/pdb4yep/pdb
PDB entry 4yep coloured by chain, front view.
PDB entry 4yep coloured by chain, side view.
PDB entry 4yep coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Laminin L4 domain structure resembles adhesion modules in ephrin receptor and other transmembrane glycoproteins.
Moran T, Gat Y, Fass D
FEBS J 282 2746-57 (2015)
PMID: 25962468

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150150 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Laminin subunit alpha-2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 185 amino acids
Theoretical weight: 21.72 KDa
Source organism: Homo sapiens
Expression system: Paenibacillus sp. UR_S19
UniProt:
  • Canonical: P24043 (Residues: 1181-1362; Coverage: 6%)
Gene names: LAMA2, LAMM
Sequence domains: Laminin B (Domain IV)

Ligands and Environments

1 bound ligand:
Ligand EDO 15 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P21212
Unit cell:
a: 57.71Å b: 131.51Å c: 44.85Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.129 0.127 0.162
Expression system: Paenibacillus sp. UR_S19

Quick links

Citations

4 citation in other articles

Comprehensive Endogenous Tagging of Basement Membrane Components Reveals Dynamic Movement within the Matrix Scaffolding.
Keeley et al. (2020)
3 more

6 mentions without citation

Structural biology of laminins.
Hohenester E. (2019)
5 more