› 4y7s

X-ray diffraction
2Å resolution

Crystal Structure of the CFEM protein Csa2

Released:
DOI: 10.2210/pdb4y7s/pdb
PDB entry 4y7s coloured by chain, front view.
PDB entry 4y7s coloured by chain, side view.
PDB entry 4y7s coloured by chain, top view.
Source organism: Candida albicans
Primary publication:
Structural basis of haem-iron acquisition by fungal pathogens.
Nasser L, Weissman Z, Pinsky M, Amartely H, Dvir H, Kornitzer D
Nat Microbiol 1 16156 (2016)
PMID: 27617569

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-176859 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Secreted hemophore CSA2 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 111 amino acids
Theoretical weight: 11.66 KDa
Source organism: Candida albicans
Expression system: Escherichia coli
UniProt:
  • Canonical: Q5A0X8 (Residues: 34-144; Coverage: 87%)
Gene names: CAALFM_C406920CA, CRW1, CSA2, CaO19.10629, CaO19.3117
Sequence domains: CFEM domain

Ligands and Environments

3 bound ligands:
Ligand HEB 3 x HEB
Ligand CL 1 x CL
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-X
Spacegroup: P212121
Unit cell:
a: 61.341Å b: 61.208Å c: 97.3Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.154 0.153 0.192
Expression system: Escherichia coli

Quick links

Citations

11 review citations

The impact of the Fungus-Host-Microbiota interplay upon Candida albicans infections: current knowledge and new perspectives.
d'Enfert et al. (2021)
10 more

2 mentions without citation

Heme Scavenging and Delivery: The Role of Human Serum Albumin.
De Simone et al. (2023)
1 more