› 4y03

X-ray diffraction
1.94Å resolution

Crystal Structure of the fifth bromodomain of human PB1 in complex with salicylic acid

Released:
DOI: 10.2210/pdb4y03/pdb
PDB entry 4y03 coloured by chain, front view.
PDB entry 4y03 coloured by chain, side view.
PDB entry 4y03 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Filippakopoulos P, Picaud S, Felletar I, Fedorov O, von Delft F, Edwards AM, Arrowsmith CH, Bountra C, Knapp S, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183177 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein polybromo-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 124 amino acids
Theoretical weight: 14.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q86U86 (Residues: 645-766; Coverage: 7%)
Gene names: BAF180, PB1, PBRM1
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

2 bound ligands:
Ligand SAL 2 x SAL
Ligand CIT 1 x CIT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: P212121
Unit cell:
a: 41.68Å b: 58.48Å c: 139.13Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.234 0.232 0.281
Expression system: Escherichia coli BL21(DE3)

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