› 4xli

X-ray diffraction
2.5Å resolution

Crystal structure of Abl2/Arg kinase in complex with dasatinib

Released:
DOI: 10.2210/pdb4xli/pdb
PDB entry 4xli coloured by chain, front view.
PDB entry 4xli coloured by chain, side view.
PDB entry 4xli coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structure of the ABL2/ARG kinase in complex with dasatinib.
Ha BH, Simpson MA, Koleske AJ, Boggon TJ
Acta Crystallogr F Struct Biol Commun 71 443-8 (2015)
PMID: 25849507

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-175582 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase ABL2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 268 amino acids
Theoretical weight: 30.77 KDa
Source organism: Mus musculus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q4JIM5 (Residues: 279-546; Coverage: 23%)
Gene names: Abl2, Arg
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand 1N1 2 x 1N1
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P65
Unit cell:
a: 109.688Å b: 109.688Å c: 121.52Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.157 0.154 0.205
Expression system: Trichoplusia ni

Quick links

Citations

1 review citation

miR-142: A Master Regulator in Hematological Malignancies and Therapeutic Opportunities.
Huang et al. (2023)
3 other articles

2 mentions without citation

Structure of the ABL2/ARG kinase in complex with dasatinib.
Ha et al. (2015)
1 more