› 4wi9

X-ray diffraction
2.65Å resolution

Structural mapping of the human IgG1 binding site for FcRn: hu3S193 Fc mutation I253A/H310A

Released:
DOI: 10.2210/pdb4wi9/pdb
PDB entry 4wi9 coloured by chain, front view.
PDB entry 4wi9 coloured by chain, side view.
PDB entry 4wi9 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Farrugia W, Burvenich IJG, Scott AM, Ramsland PA

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134849 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (4 distinct):
Immunoglobulin heavy constant gamma 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 208 amino acids
Theoretical weight: 23.53 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01857 (Residues: 120-327; Coverage: 52%)
Gene name: IGHG1
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, FUC, BMA, MAN
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX1
Spacegroup: P212121
Unit cell:
a: 49.163Å b: 77.654Å c: 140.897Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.213 0.206 0.274
Expression system: Homo sapiens

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