› 4upg

X-ray diffraction
2.1Å resolution

X-ray structure of calcium-free human sorcin

Released:
DOI: 10.2210/pdb4upg/pdb
PDB entry 4upg coloured by chain, front view.
PDB entry 4upg coloured by chain, side view.
PDB entry 4upg coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of Sorcin-mediated calcium-dependent signal transduction.
Ilari A, Fiorillo A, Poser E, Lalioti VS, Sundell GN, Ivarsson Y, Genovese I, Colotti G
Sci Rep 5 16828 (2015)
PMID: 26577048

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151780 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sorcin Chain: A
Molecule details ›
Chain: A
Length: 169 amino acids
Theoretical weight: 19.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P30626 (Residues: 30-198; Coverage: 85%)
Gene name: SRI
Sequence domains:
Structure domains: EF-hand

Ligands and Environments

2 bound ligands:
Ligand SO4 5 x SO4
Ligand PEG 2 x PEG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ELETTRA BEAMLINE 5.2R
Spacegroup: I422
Unit cell:
a: 106.45Å b: 106.45Å c: 77.477Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.183 0.181 0.22
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

Sorcin a Potential Molecular Target for Cancer Therapy.
Shabnam et al. (2018)
2 more

4 mentions without citation

Structural basis of Sorcin-mediated calcium-dependent signal transduction.
Ilari et al. (2015)
3 more