› 4unp

X-ray diffraction
2.3Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + dTMP = ADP + dTDP
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161735 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thymidylate kinase Chain: A
Molecule details ›
Chain: A
Length: 210 amino acids
Theoretical weight: 22.26 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli
UniProt:
  • Canonical: P9WKE1 (Residues: 1-210; Coverage: 98%)
Gene names: Rv3247c, tmk
Sequence domains: Thymidylate kinase
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

1 bound ligand:
Ligand TXW 1 x TXW
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P3221
Unit cell:
a: 65.14Å b: 65.14Å c: 134.818Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.188 0.187 0.214
Expression system: Escherichia coli

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Citations

6 review citations

Recent advances of pyrazole-containing derivatives as anti-tubercular agents.
Xu et al. (2017)
5 more