4um9

X-ray diffraction
2.5Å resolution

Crystal structure of alpha V beta 6 with peptide

Released:
Source organism: Homo sapiens
Primary publication:
Structural determinants of integrin β-subunit specificity for latent TGF-β.
Nat Struct Mol Biol 21 1091-6 (2014)
PMID: 25383667

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-219228 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (8 distinct):
Integrin alpha-V heavy chain Chains: A, C
Molecule details ›
Chains: A, C
Length: 604 amino acids
Theoretical weight: 66.41 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P06756 (Residues: 31-625; Coverage: 58%)
Gene names: ITGAV, MSK8, VNRA, VTNR
Sequence domains:
Structure domains:
Integrin beta-6 Chain: B
Molecule details ›
Chain: B
Length: 483 amino acids
Theoretical weight: 52.99 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P18564 (Residues: 18-491; Coverage: 61%)
Gene name: ITGB6
Sequence domains:
Structure domains:
Integrin beta-6 Chain: D
Molecule details ›
Chain: D
Length: 483 amino acids
Theoretical weight: 52.96 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P18564 (Residues: 18-491; Coverage: 61%)
Gene name: ITGB6
Sequence domains:
Structure domains:
Latency-associated peptide Chains: E, F
Molecule details ›
Chains: E, F
Length: 13 amino acids
Theoretical weight: 1.27 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P10600 (Residues: 259-269; Coverage: 3%)
Gene name: TGFB3

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, MAN, BMA
Carbohydrate polymer : NEW Components: NAG, MAN, BMA
Carbohydrate polymer : NEW Components: NAG, BMA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: C2
Unit cell:
a: 185.02Å b: 168.09Å c: 101.8Å
α: 90° β: 98.95° γ: 90°
R-values:
R R work R free
0.223 0.222 0.266
Expression system: Homo sapiens