› 4ucc

X-ray diffraction
2.05Å resolution

N-terminal globular domain of the RSV Nucleoprotein in complex with the Nucleoprotein Phosphoprotein interaction inhibitor M76

Released:
DOI: 10.2210/pdb4ucc/pdb
PDB entry 4ucc coloured by chain, front view.
PDB entry 4ucc coloured by chain, side view.
PDB entry 4ucc coloured by chain, top view.
Source organism: Human respiratory syncytial virus A2
Primary publication:
A Druggable Pocket at the Nucleocapsid/Phosphoprotein Interaction Site of Human Respiratory Syncytial Virus.
Ouizougun-Oubari M, Pereira N, Tarus B, Galloux M, Lassoued S, Fix J, Tortorici MA, Hoos S, Baron B, England P, Desmaële D, Couvreur P, Bontems F, Rey FA, Eléouët JF, Sizun C, Slama-Schwok A, Duquerroy S
J Virol 89 11129-43 (2015)
PMID: 26246564

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136968 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nucleoprotein Chains: A, B
Molecule details ›
Chains: A, B
Length: 233 amino acids
Theoretical weight: 26.27 KDa
Source organism: Human respiratory syncytial virus A2
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P03418 (Residues: 31-252; Coverage: 57%)
Gene name: N
Sequence domains: Pneumovirus nucleocapsid protein

Ligands and Environments

1 bound ligand:
Ligand ZKW 2 x ZKW
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P212121
Unit cell:
a: 34.82Å b: 71.96Å c: 178.17Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.196 0.191 0.236
Expression system: Escherichia coli BL21

Quick links

Citations

11 review citations

Respiratory Syncytial Virus: Infection, Detection, and New Options for Prevention and Treatment.
Griffiths et al. (2017)
10 more

5 mentions without citation

Overview of Viral Pneumonia Associated With Influenza Virus, Respiratory Syncytial Virus, and Coronavirus, and Therapeutics Based on Natural Products of Medicinal Plants.
Hu et al. (2021)
4 more