› 4u2a

X-ray diffraction
1.74Å resolution

Structure of a lectin from the seeds of Vatairea macrocarpa complexed with GalNAc

Released:
DOI: 10.2210/pdb4u2a/pdb
PDB entry 4u2a coloured by chain, front view.
PDB entry 4u2a coloured by chain, side view.
PDB entry 4u2a coloured by chain, top view.
Source organism: Vatairea macrocarpa
Primary publication:
High-resolution structure of a new Tn antigen-binding lectin from Vatairea macrocarpa and a comparative analysis of Tn-binding legume lectins.
Sousa BL, Silva Filho JC, Kumar P, Pereira RI, Łyskowski A, Rocha BA, Delatorre P, Bezerra GA, Nagano CS, Gruber K, Cavada BS
Int J Biochem Cell Biol 59 103-10 (2015)
PMID: 25499445

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160511 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Seed lectin Chain: A
Molecule details ›
Chain: A
Length: 240 amino acids
Theoretical weight: 26.22 KDa
Source organism: Vatairea macrocarpa
UniProt:
  • Canonical: P81371 (Residues: 1-240; Coverage: 100%)
Sequence domains: Legume lectin domain
Structure domains: Jelly Rolls

Ligands and Environments

6 bound ligands:
Ligand CA 1 x CA
Ligand MN 1 x MN
Ligand A2G 1 x A2G
Ligand CIT 1 x CIT
Ligand GOL 2 x GOL
Ligand SO4 3 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: I222
Unit cell:
a: 56.262Å b: 85.52Å c: 129.416Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.163 0.162 0.188

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Citations

3 review citations

Plant Lectins Targeting O-Glycans at the Cell Surface as Tools for Cancer Diagnosis, Prognosis and Therapy.
Poiroux et al. (2017)
2 more

1 mention without citation

Research advances and prospects of legume lectins.
Katoch et al. (2021)