› 4tzc

X-ray diffraction
1.88Å resolution

Crystal Structure of Murine Cereblon in Complex with Thalidomide

Released:
DOI: 10.2210/pdb4tzc/pdb
PDB entry 4tzc coloured by chain, front view.
PDB entry 4tzc coloured by chain, side view.
PDB entry 4tzc coloured by chain, top view.
Source organism: Mus musculus
Entry authors: Chamberlain PP, Pagarigan B, Delker S, Leon B

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183941 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein cereblon Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 108 amino acids
Theoretical weight: 12.06 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8C7D2 (Residues: 322-428; Coverage: 24%)
Gene name: Crbn
Sequence domains: Yippee zinc-binding/DNA-binding /Mis18, centromere assembly
Structure domains: Peptide methionine sulfoxide reductase.

Ligands and Environments

3 bound ligands:
Ligand ZN 4 x ZN
Ligand EF2 4 x EF2
Ligand SO4 8 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: I23
Unit cell:
a: 143.146Å b: 143.146Å c: 143.146Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.175 0.173 0.22
Expression system: Escherichia coli

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