› 4tz4

X-ray diffraction
3.01Å resolution

Crystal Structure of Human Cereblon in Complex with DDB1 and Lenalidomide

Released:
DOI: 10.2210/pdb4tz4/pdb
PDB entry 4tz4 coloured by chain, front view.
PDB entry 4tz4 coloured by chain, side view.
PDB entry 4tz4 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Chamberlain PP, Pagarigan B, Delker S, Leon B, Riley M

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172480 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
DNA damage-binding protein 1 Chain: A
Molecule details ›
Chain: A
Length: 1146 amino acids
Theoretical weight: 127.88 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q16531 (Residues: 2-1140; Coverage: 100%)
Gene names: DDB1, XAP1
Sequence domains:
Structure domains:
Protein cereblon Chain: C
Molecule details ›
Chain: C
Length: 381 amino acids
Theoretical weight: 43.87 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q96SW2 (Residues: 48-428; Coverage: 86%)
Gene names: AD-006, CRBN
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand ZN 1 x ZN
Ligand LVY 1 x LVY
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: P212121
Unit cell:
a: 71.862Å b: 129.117Å c: 198.677Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.205 0.202 0.271
Expression system: Spodoptera frugiperda

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