› 4roa

X-ray diffraction
1.9Å resolution

1.90A resolution structure of SRPN2 (S358W) from Anopheles gambiae

Released:
DOI: 10.2210/pdb4roa/pdb
PDB entry 4roa coloured by chain, front view.
PDB entry 4roa coloured by chain, side view.
PDB entry 4roa coloured by chain, top view.
Source organism: Anopheles gambiae
Primary publication:
Structural and inhibitory effects of hinge loop mutagenesis in serpin-2 from the malaria vector Anopheles gambiae.
Zhang X, Meekins DA, An C, Zolkiewski M, Battaile KP, Kanost MR, Lovell S, Michel K
J Biol Chem 290 2946-56 (2015)
PMID: 25525260

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-181881 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine protease inhibitor 2 Chain: A
Molecule details ›
Chain: A
Length: 397 amino acids
Theoretical weight: 45.46 KDa
Source organism: Anopheles gambiae
Expression system: Escherichia coli
UniProt:
  • Canonical: Q7QIJ8 (Residues: 22-409; Coverage: 100%)
Gene names: 1270169, AgaP_AGAP006911, SRPN2
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P63
Unit cell:
a: 96.946Å b: 96.946Å c: 78.569Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.174 0.172 0.21
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Serpins in arthropod biology.
Meekins et al. (2017)
5 other articles

1 mention without citation

Structural and inhibitory effects of hinge loop mutagenesis in serpin-2 from the malaria vector Anopheles gambiae.
Zhang et al. (2015)