› 4qvz

X-ray diffraction
3.2Å resolution

FMRP N-terminal domain

Released:
DOI: 10.2210/pdb4qvz/pdb
PDB entry 4qvz coloured by chain, front view.
PDB entry 4qvz coloured by chain, side view.
PDB entry 4qvz coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Human FMRP contains an integral tandem Agenet (Tudor) and KH motif in the amino terminal domain.
Myrick LK, Hashimoto H, Cheng X, Warren ST
Hum Mol Genet 24 1733-40 (2015)
PMID: 25416280

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170388 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fragile X messenger ribonucleoprotein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 214 amino acids
Theoretical weight: 24.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q06787 (Residues: 1-213; Coverage: 34%)
Gene name: FMR1
Sequence domains:
Structure domains: SH3 type barrels.

Ligands and Environments

1 bound ligand:
Ligand EDO 2 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P43212
Unit cell:
a: 89.538Å b: 89.538Å c: 118.079Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.257 0.254 0.304
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

22 review citations

Altered Neuronal and Circuit Excitability in Fragile X Syndrome.
Contractor et al. (2015)
21 more

6 mentions without citation

Human FMRP contains an integral tandem Agenet (Tudor) and KH motif in the amino terminal domain.
Myrick et al. (2015)
5 more