› 4p60

X-ray diffraction
2.4Å resolution

Structure of the N-terminal domain of the human mitochondrial aspartate/glutamate carrier Aralar in the apo state

Released:
DOI: 10.2210/pdb4p60/pdb
PDB entry 4p60 coloured by chain, front view.
PDB entry 4p60 coloured by chain, side view.
PDB entry 4p60 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Calcium-induced conformational changes of the regulatory domain of human mitochondrial aspartate/glutamate carriers.
Thangaratnarajah C, Ruprecht JJ, Kunji ER
Nat Commun 5 5491 (2014)
PMID: 25410934

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131111 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial Chains: A, B
Molecule details ›
Chains: A, B
Length: 315 amino acids
Theoretical weight: 35.8 KDa
Source organism: Homo sapiens
Expression system: Lactococcus lactis subsp. cremoris NZ9000
UniProt:
  • Canonical: O75746 (Residues: 2-311; Coverage: 46%)
Gene names: AGC1, ARALAR1, SLC25A12

Ligands and Environments

1 bound ligand:
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P6322
Unit cell:
a: 103.52Å b: 103.52Å c: 185.559Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.248 0.245 0.297
Expression system: Lactococcus lactis subsp. cremoris NZ9000

Quick links

Citations

19 review citations

The SLC25 Mitochondrial Carrier Family: Structure and Mechanism.
Ruprecht et al. (2020)
18 more

3 mentions without citation

Calcium-induced conformational changes of the regulatory domain of human mitochondrial aspartate/glutamate carriers.
Thangaratnarajah et al. (2014)
2 more