› 4p0k

X-ray diffraction
1.7Å resolution

Crystal Structure of Double Loop-Swapped Interleukin-36Ra

Released:
DOI: 10.2210/pdb4p0k/pdb
PDB entry 4p0k coloured by chain, front view.
PDB entry 4p0k coloured by chain, side view.
PDB entry 4p0k coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular determinants of agonist and antagonist signaling through the IL-36 receptor.
Günther S, Sundberg EJ
J Immunol 193 921-30 (2014)
PMID: 24935927

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192743 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interleukin-36 gamma; Interleukin-36 receptor antagonist protein Chain: A
Molecule details ›
Chain: A
Length: 154 amino acids
Theoretical weight: 16.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9UBH0 (Residues: 2-49, 55-138, 148-155; Coverage: 89%)
  • Canonical: Q9NZH8 (Residues: 64-72, 155-161; Coverage: 10%)
Gene names: FIL1D, IL1E, IL1F5, IL1F9, IL1H1, IL1HY1, IL1L1, IL1RP2, IL1RP3, IL36G, IL36RN, UNQ1896/PRO4342, UNQ2456/PRO5737
Sequence domains: Interleukin-1 / 18
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: P3121
Unit cell:
a: 43.115Å b: 43.115Å c: 119.122Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.197 0.195 0.233
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

16 review citations

The family of the interleukin-1 receptors.
Boraschi et al. (2018)
15 more

1 mention without citation

Structural Basis of IL-1 Family Cytokine Signaling.
Fields et al. (2019)