4o45

X-ray diffraction
1.87Å resolution

WDR5 in complex with influenza NS1 C-terminal tail

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-137073 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
WD repeat-containing protein 5 Chain: A
Molecule details ›
Chain: A
Length: 312 amino acids
Theoretical weight: 34.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P61964 (Residues: 24-334; Coverage: 93%)
Gene names: BIG3, WDR5
Sequence domains: WD domain, G-beta repeat
Structure domains: YVTN repeat-like/Quinoprotein amine dehydrogenase
Non-structural protein 1 Chain: B
Molecule details ›
Chain: B
Length: 15 amino acids
Theoretical weight: 1.79 KDa
Source organism: Influenza A virus H3N2
Expression system: Not provided
UniProt:
  • Canonical: P03495 (Residues: 216-230; Coverage: 6%)
Gene name: NS

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21212
Unit cell:
a: 81.218Å b: 85.83Å c: 40.4Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.176 0.174 0.212
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided