› 4nyk

X-ray diffraction
3Å resolution

Structure of a membrane protein

Released:
DOI: 10.2210/pdb4nyk/pdb
PDB entry 4nyk coloured by chain, front view.
PDB entry 4nyk coloured by chain, side view.
PDB entry 4nyk coloured by chain, top view.
Source organism: Gallus gallus
Primary publication:
Pore architecture and ion sites in acid-sensing ion channels and P2X receptors.
Gonzales EB, Kawate T, Gouaux E
Nature 460 599-604 (2009)
PMID: 19641589

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-173089 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Acid-sensing ion channel 1 Chain: A
Molecule details ›
Chain: A
Length: 470 amino acids
Theoretical weight: 53.55 KDa
Source organism: Gallus gallus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q1XA76 (Residues: 2-466; Coverage: 88%)
Gene names: ACCN2, ASIC1
Sequence domains: Amiloride-sensitive sodium channel
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: R3
Unit cell:
a: 131.787Å b: 131.787Å c: 119.107Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.204 0.202 0.246
Expression system: Spodoptera frugiperda

Quick links

Citations

87 review citations

Cellular function and molecular structure of ecto-nucleotidases.
Zimmermann et al. (2012)
86 more

29 mentions without citation

Regulating ENaC's gate.
Kleyman et al. (2020)
28 more