› 4n7i

X-ray diffraction
1.4Å resolution

Crystal Structure of Intracellular B30.2 Domain of BTN3A1

Released:
DOI: 10.2210/pdb4n7i/pdb
PDB entry 4n7i coloured by chain, front view.
PDB entry 4n7i coloured by chain, side view.
PDB entry 4n7i coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The intracellular B30.2 domain of butyrophilin 3A1 binds phosphoantigens to mediate activation of human Vγ9Vδ2 T cells.
Sandstrom A, Peigné CM, Léger A, Crooks JE, Konczak F, Gesnel MC, Breathnach R, Bonneville M, Scotet E, Adams EJ
Immunity 40 490-500 (2014)
PMID: 24703779

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-126303 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Butyrophilin subfamily 3 member A1 Chain: A
Molecule details ›
Chain: A
Length: 190 amino acids
Theoretical weight: 21.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: O00481 (Residues: 328-513; Coverage: 38%)
Gene names: BTF5, BTN3A1
Sequence domains:
Structure domains: Jelly Rolls

Ligands and Environments

4 bound ligands:
Ligand GOL 2 x GOL
Ligand BME 2 x BME
Ligand MG 1 x MG
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Unit cell:
a: 39.032Å b: 44.957Å c: 124.813Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.137 0.135 0.166
Expression system: Escherichia coli BL21

Quick links

Citations

118 review citations

The burgeoning family of unconventional T cells.
Godfrey et al. (2015)
117 more

8 mentions without citation

The intracellular B30.2 domain of butyrophilin 3A1 binds phosphoantigens to mediate activation of human Vγ9Vδ2 T cells.
Sandstrom et al. (2014)
7 more