› 4mtg

X-ray diffraction
3.3Å resolution

Structural Basis for Ca2+ Selectivity of a Voltage-gated Calcium Channel

Released:
DOI: 10.2210/pdb4mtg/pdb
PDB entry 4mtg coloured by chain, front view.
PDB entry 4mtg coloured by chain, side view.
PDB entry 4mtg coloured by chain, top view.
Source organism: Aliarcobacter butzleri RM4018
Primary publication:
Structural basis for Ca2+ selectivity of a voltage-gated calcium channel.
Tang L, Gamal El-Din TM, Payandeh J, Martinez GQ, Heard TM, Scheuer T, Zheng N, Catterall WA
Nature 505 56-61 (2014)
PMID: 24270805

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-108631 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ion transport domain-containing protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 237 amino acids
Theoretical weight: 27.46 KDa
Source organism: Aliarcobacter butzleri RM4018
Expression system: Trichoplusia ni
UniProt:
  • Canonical: A8EVM5 (Residues: 1-219; Coverage: 82%)
Gene name: Abu_1752
Sequence domains: Ion transport protein
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand CA 2 x CA
Ligand PX4 16 x PX4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: C2
Unit cell:
a: 177.25Å b: 177.74Å c: 131.02Å
α: 90° β: 132.59° γ: 90°
R-values:
R R work R free
0.241 0.24 0.272
Expression system: Trichoplusia ni

Quick links

Citations

48 review citations

Store-Operated Calcium Channels.
Prakriya et al. (2015)
47 more

6 mentions without citation

Structural basis for Ca2+ selectivity of a voltage-gated calcium channel.
Tang et al. (2014)
5 more