› 4m8m

X-ray diffraction
3.31Å resolution

Crystal structure of the active dimer of zebrafish PlexinC1 cytoplasmic region

Released:
DOI: 10.2210/pdb4m8m/pdb
PDB entry 4m8m coloured by chain, front view.
PDB entry 4m8m coloured by chain, side view.
PDB entry 4m8m coloured by chain, top view.
Source organism: Danio rerio
Primary publication:
Structural basis for activation and non-canonical catalysis of the Rap GTPase activating protein domain of plexin.
Wang Y, Pascoe HG, Brautigam CA, He H, Zhang X
Elife 2 e01279 (2013)
PMID: 24137545

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-177782 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sema domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 632 amino acids
Theoretical weight: 73.12 KDa
Source organism: Danio rerio
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q5RGW1 (Residues: 456-1056; Coverage: 57%)
Gene name: plxnc1
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P212121
Unit cell:
a: 53.216Å b: 146.1Å c: 209.581Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.228 0.226 0.282
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

7 review citations

Semaphorins and plexins as therapeutic targets.
Worzfeld et al. (2014)
6 more

3 mentions without citation

Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance.
van der Klaauw et al. (2019)
2 more